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Since the synergy is triggered by reloading the Heroine/Megahand gun while holding any of the three other guns. No surprise since the weapon is a reference to Megaman blaster. It had normal animation like when you pick up item/gun that grants synergy but gun doesn't changed appearance (i checked wiki for this) and gun overall all works like normal heroine.

Megahand has a similar mechanic too, but offers even more alternate modes - eight. Like above i've had a problem with this synergy.
